Rickettsiosis Complications Due to Late Diagnosis in the Pediatric Patient

Complicaciones de Rickettsiosis debido al Diagnóstico Tardío en el Paciente Pediátrico

Authors

  • Manuel A. Cano-Rangel Hospital Infantil del Estado de Sonora
  • Adriana E. Buzani-Peña Universidad Durango Santander
  • Dario Páez-Douriet Universidad Durango Santander https://orcid.org/0009-0007-9518-4496
  • Alberto Ramón-Ríos Universidad Durango Santander
  • Alberto Ramírez-Mexía Universidad Durango Santander
  • Manuel R. Ramírez-Mexía Universidad Durango Santander

DOI:

https://doi.org/10.59420/remus.8.2022.113

Keywords:

rickettsiosis, complications, pediatrics

Abstract

Rickettsiosis are a group of diseases caused by gram-negative coco-bacilli of the Rickettsia genus that are distributed among hematophagous arthropod vectors such as ticks, fleas, lice, or mites. Within Sonora, rickettsiosis plays a more important role due to the dry climate in the zone which favors its prevalence and incidence year after year. For this reason, it is considered an endemic disease of the state and of epidemiological importance.

The common clinical manifestations are usually characterized by febrile episodes, myalgia, headache and general malaise, making it a pathology that represents a diagnostic challenge for the first contact health personnel due to its non-specific manifestations, which makes it susceptible to developing complications, especially if an early diagnosis or suspicion are not made, that could allow us to start with an adequate therapy; particularly in pediatric patients, the complications are severe and catastrophic for both the relatives and the patient, they were related to multi-organ failure, more frequently we found affected the neurological, renal, vascular and hepatic systems; and it must be considered that all of these can culminate in the death of the patient.

Currently, scientific data is limited regarding information on rickettsiosis in pediatric patients and its potential complications. Therefore, this article seeks to disseminate the necessary information in these scenarios, with the aim of not underestimating possible diagnoses within the pediatric population, since it is one of the most vulnerable groups to be exposed to the disease, as well as its possible complications due to the inability to objectively communicating their condition.

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References

Santamaría-Arza C, Reyes-Gómez U, Reyes-Hernández K, López-Cruz G, López-Días A, Quero-Hernández A, et al. Rickettsiosis conceptos básicos. Sal Jal [Internet]. 2018 [citado el 05 de mayo de 2022];5(2):113–21. (Enlace)

Noor A. Pediatric Rocky Mountain Spotted Fever [Internet] Medscape. 2021]. (Enlace)

López-Castillo DC, Vaquera-Aparicio D, González-Soto MA, Martínez-Ramírez R, Rodríguez-Muñoz L, Solórzano-Santos F. Fiebre manchada de montañas rocosas: experiencia en 5 años de vigilancia activa en un hospital pediátrico de segundo nivel en el noreste de México. Bol Med Hosp Infant Mex [Internet]. 2018;75(5):303–8. (Enlace)

Blanton LS. The rickettsioses: A practical update. Infect Dis Clin North Am [Internet]. 2019;33(1):213–29. http://dx.doi.org/10.1016/j.idc.2018.10.010.

Martinez-Medina M. A 15 años de la reemergencia de la fiebre manchada en Sonora. [Internet]. HIES. 2018. (Enlace)

Reyes-Castro PA, Ernst KC, Walker KR, Hayden MH, Alvarez-Hernandez G. Knowledge, attitudes, and practices related to Rocky Mountain spotted fever in Hermosillo, México. Am J Trop Med Hyg [Internet]. 2021;104(1):184–9. (Enlace)

Oliver H. Voss and M. Sayeedur Rahman. Rickettsia-host interaction: strategies of intra cytosolic host colonization. Pathogens and Disease [Internet]. (Enlace)

Patel S, Bronze M. Rocky Mountain Spotted Fever (RMSF) [Internet]. Medscape. 2021. (Enlace)

González AS, Arjona RG, Guerrero PP, Roca JSR. Infecciones por Rickettsia y fiebre Q. Medicine [Internet]. 2022;13(54):3163–72. (Enlace)

R, Jorge & V, Salim&GonzalezTous, Marco.[internet] (2017). Rickettsiosis. Revista MVZ Córdoba. 22. 6118. 10.21897/rmvz.1080. (Enlace)

Fischer M. Rickettsioses: Cutaneous findings frequently lead to diagnosis – a review. Journal of the German Society of Dermatology [Internet]. 2018;16(12):1459–76. (Enlace)

EmmanouilGalanakis, MD, PhD, and Maria Bitsori. When to Think of Rickettsia. The Pediatric Infectious Disease Journal [Internet]. Junio de 2019;38(65):S20–3. (Enlace)

Sood& Amit Sachdeva A. Rickettsioses in Children – A Review. TheIndianJournal of Pediatrics [Internet]. el 28 de febrero de 2020;87(1):930–6. (Enlace)

Snowden J, Simonsen KA. Rickettsia Rickettsii. [internet]. PubMed. 2021. (Enlace)

von Fricken ME, Voorhees MA, Koehler JW, Asbun C, Lam B, Qurollo B, et al. Molecular characteristics of Rickettsia in ticks collected along the southern border of Mongolia. Pathogens [Internet]. 2020;9(11):943. (Enlace)

Rathore M, Steele R. Rickettsial Infection [Internet]. Medscape. 2021. (Enlace)

Delgado-De la Mora J, Licona-Enríquez JD, Leyva-Gastélum M, Delgado-De la Mora D, Rascón-Alcantar A, Álvarez-Hernández G. A fatal case series of Rocky Mountain spottedfever in Sonora, México. Biomédica [Internet]. 2018 [citado el 15 de mayo de 2022];38(1):69–76. (Enlace)

Sekeyová Z, Danchenko M, Filipčík P, Fournier PE. Rickettsial infections of the central nervous system. PLoSNeglTropDis [Internet]. 2019;13(8):e0007469. (Enlace)

Prevención, diagnóstico y tratamiento de la fiebre manchada por Rickettsia rickettsii en población pediátrica y adulta, en el primer y segundo nivel de atención. México: Secretaría de Salud; 21/Marzo/2013.

Alvarez-Hernandez G, Ernst K, Acuña-Melendrez NH, Vargas-Ortega AP, Candia-Plata MDC. Medical knowledge related to Rocky Mountain spotted fever in Sonora, Mexico. Trans R Soc Trop Med Hyg [Internet]. 2018;112(3):109–14. (Enlace)

Bainade KS, Kotrashetti VA, Baburao Sonawane V, Ahuja S, Bhatarkar S. Hepatitis due to rickettsial fever: A case report. Indian J Child Health (Bhopal) [Internet]. 2021;8(2):104–6. (Enlace)

Baltadzhiev I, Zaprianov Z, Baltadjiev A. Renal involvement in Mediterranean spotted fever: Clinical and histopathological data. Med PrincPract [Internet]. 2021;30(4):369–75.(Enlace)

Olagorta García S, Esteban Ciriano ME, Belloc SJ, García Irure JJ. Fallo multiorgánico secundario a Rickettsiaconorii. Revista de la Asociación Mexicana de Medicina Crítica y Terapia Intensiva [Internet]. 2012 [citado el 05 de mayo de 2022];26(3):166–70. (Enlace)

Sharabi S, Sagi O, Ben-Shimol S. Serologic diagnosis of acute rickettsiosis in children in southern Israel. PediatrInfectDis J [Internet]. 2021;40(12):e521–3. (Enlace)

Solís-Alvarado E, Martínez-Contreras A., Haro-Acosta M., Johanna-Caro V, Álvarez-Cano J, et al. Factores asociados a la letalidad por rickettsiosis transmitida por garrapatas en el HGZ No. 30 de Mexicali, Baja California. [Tesis de especialidad]. Mexicali: Universidad Autónoma de Baja California. 2018 [citado el 09 de Mayo]. Número de registro R-2018-201-013. (Enlace)

Chung IH, Robinson LK, Stewart-Juba JJ, Dasch GA, Kato CY. Analytically sensitive Rickettsia species detection for laboratory diagnosis. Am J TropMedHyg [Internet]. 2022 [citado el 15 de mayo de 2022];106(5):1352–7. (Enlace)

Pérez JE, Estrada GI, Zapata Y, Hidalgo M, Serna CC, Castro DC, et al. Frecuencia de anticuerpos y seroconversión frente a Rickettsia spp. en pacientes atendidos en instituciones de salud del departamento de Caldas, Colombia, 2016-2019. Biomédica [Internet]. 2021 [citado el 15 de mayo de 2022];41(Sp. 2):103–17. (Enlace)

Sood AK, Sachdeva A. Rickettsioses in children - A review. Indian J Pediatr [Internet]. 2020;87(11):930–6. Disponible en: http://dx.doi.org/10.1007/s12098-020-03216-z.

Krawiec C, Ceneviva GD, Zhou S, Thomas NJ. Impact of a severe Rocky Mountain spotted fever case on treatment practices at an academic institution within a nonendemic area. Wilderness Environ Med [Internet]. 2021;32(4):427–32.

Vicente D, Pérez-Trallero E. Tetracyclines, sulfonamides, and metronidazole. EnfermInfeccMicrobiolClin [Internet]. 2010;28(2):122–30. Disponible en: http://dx.doi.org/10.1016/j.eimc.2009.10.002

Martínez-Medina MÁ, Pérez-Jacinto AA. Administración de líquidos endovenosos y letalidad en niños con fiebre manchada. BolClinHosp Infant Edo Son. 2018;35(2):92-98.

Martínez-Medina MÁ, Rascón-Alcantar A. Complications and causes of death in Mexican children with Rocky Mountain spotted fever. Gac Med Mex. 2016;152(6):789–95

Galanakis E, Bitsori M. When to think of Rickettsia. Pediatr Infect Dis J [Internet]. 2019;38(6S Suppl 1):S20–3. Disponibleen:

http://dx.doi.org/10.1097/INF.0000000000002320

Chiranth SB, Ashwini KR, Gowda VK, Sanjay KS, Ahmed M, Basavaraja GV. Profile of neurological manifestations in children presenting with rickettsial disease. IndianPediatr [Internet]. 2022;59(3):222–5. Disponible en: http://dx.doi.org/10.1007/s13312-022-2473-x

Schmidt W-P, Devamani CS, Elangovan D, Alexander N, Rose W, Prakash JAJ. Clinical characteristics of and antibody response to spotted fever group rickettsial infections in South India: Case series and serological cohort study. Trop Med Int Health [Internet]. 2021;26(12):1616–23. Disponibleen: http://dx.doi.org/10.1111/tmi.13682

Linero K, Serrano S, Florián Rodríguez DC. Rickettsiosis: La importancia de realizar un diagnóstico precoz y manejo temprano. Revista Pediátrica de Panamá [Internet]. 2022;30–8. Disponible en: http://dx.doi.org/10.37980/im.journal.rspp.20221825

Gómez-Rivera N, Gómez-Jiménez IA, Fonseca-Chon I, García-Zárate MG, Gómez-Figueroa CO, Villalobos-García L, et al. Factores relacionados con la mortalidad en niños con fiebre manchada de las montañas rocosas: análisis de 14 años en Sonora, México. Revista mexicana de pediatría [Internet]. 2019 [cited 2022 May 07];86(1):8–12. Available from:

http://www.scielo.org.mx/scielo.php?pid=S0035-00522019000100008&script=sci_arttext

Delgado de la Mora J, Licona Enríquez JD, Candia-Plata M del C, Álvarez Hernández G. Discusión de factores pronóstico en dos casos familiares de fiebre manchada de las Montañas Rocosas. Acta pediátrica Méx [Internet]. 2018;39(4):323. Availablefrom: http://dx.doi.org/10.18233/apm39no4pp323-3271641

Delgado-De la Mora J, Licona-Enríquez JD, Leyva-Gastélum M, Delgado-De la Mora D, Rascón-Alcantar A, Álvarez-Hernández G. A fatal case series of Rocky Mountain spottedfever in Sonora, México. Biomédica [Internet]. 2018;38(1):69 –76. Disponible en: http://dx.doi.org/10.7705/biomedica.v38i0.3507

Lugo-Caballero C, Dzul-Rosado K, Rodríguez-Moreno G, Tello-Martín R, López-Ávila K, Zavala-Castro J. Arch Argent Pediatr [Internet]. 2017;115(1):e5–8. Disponible en: http://dx.doi.org/10.5546/aap.2017.e5

Published

2023-02-09

How to Cite

Cano-Rangel, M. A., Buzani-Peña, A. E., Páez-Douriet, D., Ramón-Ríos, A., Ramírez-Mexía, A., & Ramírez-Mexía, M. R. (2023). Rickettsiosis Complications Due to Late Diagnosis in the Pediatric Patient: Complicaciones de Rickettsiosis debido al Diagnóstico Tardío en el Paciente Pediátrico . REMUS - Revista Estudiantil De Medicina De La Universidad De Sonora (Journal of Medical Students’ of the University of Sonora), (8). https://doi.org/10.59420/remus.8.2022.113

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