Biomarcadores de consolidación ósea en diabetes mellitus tipo 2: revisión sistemática

Abstract

Abstract

Introduction: Bone healing biomarkers (BTM) have become a relevant topic in scientific research due to their impact at a systemic level, closely relating bone health to BTM levels and type 2 diabetes mellitus (T2DM). Objective: To examine in the literature the correlation of insulin resistance on BTM levels in patients with DM 2. Method: A systemic review was carried out based on the PRISMA 2020 criteria. Results: 10 studies that explored the relationship were evaluated. between BTM and T2DM. The results consistently show that T2DM is associated with reduced levels of BTM, as well as decreased bone density (p < 0.001); which poses a negative impact on bone health. Furthermore, elevated osteocalcin (OC) levels are reported to be associated with a higher risk of cardiovascular disease (OR 1.35, p = 0.014) in this population. Conclusions: Taken together, the evidence suggests that T2DM not only decreases BTM activity but could also exacerbate the risk of vascular and bone complications, thus justifying the need for more studies to improve treatment and prevention strategies.

Key words: endocrinology, bone, biomarkers of consolidation.